Add ½ teaspoon garlic powder, 1 large pinch salt, ¼ cup hot honey, and 1 tablespoon soy sauce to medium mixing bowl. Whisk ingredients together until fully incorporated. Set aside.
Place 4 medium salmon fillets on large plate. Pat each fillet completely dry on all sides with paper towels, then season salmon with 1 tablespoon seasoning blend of choice (or with salt and pepper).
Add seasoned salmon to large bowl used for vegetables. Pour prepared hot honey sauce over salmon fillets, then flip salmon over until all fillets are coated in hot honey sauce.
After vegetables have baked 10 minutes, carefully remove sheet pan from oven. Toss or stir vegetables, then push vegetables to one side of sheet pan to create space for salmon fillets.
Place salmon fillets on sheet pan skin-side down, making sure fillets do not touch or overlap.
Return sheet pan to oven. Roast ingredients 8 minutes.
After 8 minutes, check salmon fillets with internal meat thermometer. Continue baking salmon as needed, checking temperature often, until desired internal temperature is reached (see Notes below).
When salmon is ready, carefully remove sheet pan from oven and set aside. Let salmon rest 5 minutes.