Place large skillet on stovetop over medium heat. When pan is warm, add 2 tablespoons unsalted butter and let butter melt completely, swirling and titling pan occasionally to distribute butter across entire surface.
When butter has melted, add ½ teaspoon onion powder, ½ teaspoon cayenne pepper, 1 teaspoon dried oregano, 1 teaspoon salt, 2 teaspoons garlic powder, and 2 teaspoons paprika to skillet. Simmer spices in melted butter 30 seconds, stirring constantly.
After 30 seconds, quickly but carefully place 1 pound raw shrimp in skillet, arranging shrimp in one even layer if possible. Cook shrimp, undisturbed, 1 minute.
After 1 minute, flip shrimp over and cook 1 to 2 minutes more or until shrimp are just opaque and curled into loose "J" shape. Be careful not to overcook.
Once shrimp are cooked through, carefully transfer shrimp to serving plates. Serve warm with pasta, rice, grits, and/or grilled vegetables.