Add ½ cup hot honey, 1 teaspoon garlic powder, 2 tablespoons water, ¼ cup low-sodium soy sauce, and 1 pinch cayenne pepper (if using) to mixing bowl. Whisk ingredients together until fully incorporated.
Place 4 salmon fillets on cutting board. Season fillets generously on all sides with seasoning salt or seasoning blend of choice. Set aside.
Place large skillet on stovetop over medium-high heat. Add 1 tablespoon avocado oil and continue heating skillet until oil is hot and shimmery, tilting and swirling pan as needed to distribute oil across entire surface.
When oil is hot, place seasoned salmon fillets in skillet skin-side down. Sear salmon, undisturbed, 3 to 5 minutes or until skin is golden, crisp, and releases easily from pan. Note: if salmon skin sticks to skillet, continue searing salmon just until skin releases easily. Do not force salmon to release from pan.
Once skins are ready, remove skillet from heat and flip salmon fillets over. Let pan cool approximately 1 minute, then pour prepared hot honey sauce into skillet.
Return skillet to stovetop and reduce heat under pan to medium. Cook salmon, spooning sauce over tops of fillets often, 3 to 5 minutes or until salmon reaches desired internal temperature (see Notes below).
Once salmon has reached desired temperature, carefully transfer salmon fillets to serving plates.
Optional: if hot honey sauce is thinner than desired, return skillet to stovetop and reduce heat to low. Simmer sauce, stirring often, until desired consistency is achieved.
Spoon hot honey sauce over salmon fillets as desired. Serve warm with preferred sides.