Add compliant mayo and chipotle powder to small bowl. Whisk well until ingredients are fully combined and set aside or refrigerate until ready to use.
Add ground beef, diced bacon, sea salt, dried onion flakes, garlic powder, onion powder, and black pepper to large bowl. Using hands, mix well only until mixture is smooth and even. Be careful not to overmix.
Press ground beef mixture into bottom of bowl, creating one large, flat disc. Use knife to quarter mixture, creating 4 quarter-pound sections. Remove each section and shape mixture into hamburger patties.
Heat large skillet over medium heat. Once pan is hot, add hamburger patties, working in batches as needed to avoid overcrowding.
Cook 3 to 4 minutes, then flip and cook another 3 to 4 minutes, until burgers reach desired doneness. Transfer cooked burger patties to plate or cutting board and repeat until all patties have been cooked.
Sandwich burger patties between leaves of lettuce or portobello mushroom "buns" with spicy mayo and desired toppings. Serve warm.